Thermo Fisher Scientific LC3B Polyclonal Antibody
LC3B 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 자가포식 관련 연구에 유용합니다. 고순도 Affinity chromatography 정제 및 1 mg/mL 농도의 액상 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP1LC3B (Accession Q9GZQ8), corresponding to amino acid residues M1–P32 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900137 |
Product Specific Information
This antibody detects endogenous levels of total LC3B.
Target Information
LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B).
LC3B is associated with microtubule assembly and is important in neurogenesis. It plays a vital role in autophagy, a process that mediates the degradation of cytoplasmic components.
Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for turnover of cytoplasmic constituents and degradation of active enzymes and organelles during nutrient starvation.
LC3B mediates interactions between microtubules and cytoskeletal components and may play roles in cancer, aging, metabolic, neurodegenerative, and cardiovascular/pulmonary diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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