Thermo Fisher Scientific VEGFB Polyclonal Antibody
VEGFB 단백질의 중간 영역을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ELISA에 적합합니다. 액상 형태로 제공되며, -20°C에서 보관합니다. VEGFB는 혈관 내피세포 증식과 혈관 형성을 유도하는 성장인자로 연구용에 적합합니다.
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Thermo Fisher Scientific VEGFB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| ELISA | 1:100–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DNA immunization. This antibody is specific for the Middle Region of the target protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.01 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors characterized by eight conserved cysteine residues and shared VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis.
VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. Two alternatively spliced isoforms exist: VEGFB 167 and VEGFB 186.
- VEGFB 167: Highly basic, heparin-binding, remains associated with the cell or extracellular matrix.
- VEGFB 186: Readily secreted.
VEGFB stimulates endothelial cell proliferation and binds specifically to the tyrosine kinase receptor VEGFR1 (flt1), but not VEGFR2. It is widely expressed, most abundantly in the heart, skeletal muscle, and pancreas. VEGFB expression in human primary breast cancers has been associated with lymph node metastasis. The gene encoding VEGFB is mapped to chromosome 11q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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