Thermo Fisher Scientific LIMD1 Polyclonal Antibody
LIMD1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간 시료에 반응하며, 합성 펩타이드를 면역원으로 제작. 고순도 Affinity Chromatography 정제, 액상 형태로 제공. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human LIMD1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576727 |
Product Specific Information
Peptide sequence:
MDKYDDLGLE ASKFIEDLNM YEASKDGLFR VDKGAGNNPE FEETRRVFAT
Sequence homology:
Cow: 100%
Dog: 93%
Guinea Pig: 100%
Human: 100%
Mouse: 100%
Rabbit: 86%
Rat: 100%
Zebrafish: 100%
Target Information
The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6, and Zyxin.
Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains.
LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions.
Limd1 interacts with the proteins SQSTM1, Rb, p62, and TRAF6.
Limd1 was first identified when the deletion of its gene was noted in some cervical cancers. It blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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