Thermo Fisher Scientific VPS53 Polyclonal Antibody
VPS53 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 면역침전(IP)에 적합. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 연구용으로 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunoprecipitation (IP)
- Tested Dilution: 0.5–2 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human VPS53 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902950 |
Target Information
The sorting of acid hydrolases to lysosomes relies on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. Maintenance of this cycle requires the mammalian Golgi-associated retrograde protein (GARP) complex, composed of VPS52, VPS53, and VPS54. Depletion of any of these proteins, such as by RNAi, impairs retrograde transport of multiple TGN proteins. VPS53 has been identified as an HIV dependency factor (HDF) and is involved in viral entry, suggesting potential as a therapeutic target in HIV treatment. At least five isoforms of VPS53 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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