Thermo Fisher Scientific CH25H Polyclonal Antibody
CH25H 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 SPR에 사용 가능. 인간에 반응하며, 친화 크로마토그래피로 정제됨. 0.5 mg/mL 액상 형태로 제공되며, -20°C에서 보관. 콜레스테롤 대사 및 림프조직 내 세포 이동 연구에 적합.
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Applications
Western Blot (WB)
- Tested dilution: 1.0 µg/mL
- View 2 publications
Surface Plasmon Resonance (SPR)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of human CH25H |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689560 |
Product Specific Information
This target displays homology in the following species:
Cow: 93%; Goat: 83%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 75%; Zebrafish: 86%
Target Information
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repression of cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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