Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI1F3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Target Information

The protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily, which mediates the transport of various molecules across cellular membranes. ABC genes are categorized into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCC5 (MRP5) is part of the MRP subfamily involved in multidrug resistance and functions in the cellular export of cyclic nucleotides. This export contributes to phosphodiesterase degradation and may serve as a pathway for cyclic nucleotide elimination.

Research indicates that ABCC5 provides resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may play a role in resistance mechanisms in acute lymphoblastic leukemia and HIV-infected patients treated with nucleoside analogs.
Alternative splicing of this gene has been observed, though the complete sequence and translation initiation site remain unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.