Thermo Fisher Scientific Zyxin Monoclonal Antibody (CL2502)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

2-10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

CL2502

Immunogen

Recombinant protein corresponding to Human ZYX if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Zyxin,uniProtId:Q15942-1,ncbiNodeId:9606,antigenRange:262-382,antigenLength:572,antigenImageFileName:MA5-31367_Zyxin_Q15942-1_House_mouse.svg,antigenImageFileNamePDP:MA5-31367_Zyxin_Q15942-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2787004

Product Specific Information

Immunogen sequence: PAPKFSPVTP KFTPVASKFS PGAPGGSGSQ PNQKLGHPEA LSAGTGSPQP PSFTYAQQRE KPRVQEKQHP VPPPAQNQNQ VRSPGAPGPL TLKEVEELEQ LTQQLMQDME HPQRQNVAVN E

Target Information

Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.