Thermo Fisher Scientific SMAD4 Recombinant Rabbit Monoclonal Antibody (23GB975)
SMAD4 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. HEK293F 발현 시스템에서 생산되며, 고순도 친화 크로마토그래피 정제 및 안정적 PBS/glycerol 저장 버퍼를 사용합니다.
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Thermo Fisher Scientific SMAD4 Recombinant Rabbit Monoclonal Antibody (23GB975)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB975 |
| Immunogen | A synthetic peptide of human Smad4 (500–552AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. It is also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic (MAD) homolog 4.
Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) domains involved in DNA binding and protein interactions.
Binding of TGF-beta and BMP ligands to their receptors induces phosphorylation of receptor Smads (R-Smads: 1, 2, 3, 5, and 8), which then form a heterotrimer with Smad4 (co-Smad) and translocate to the nucleus.
Smad4 functions as a tumor suppressor by regulating transcription of target genes such as Cyclin D1 (downregulation) and collagen (upregulation), which control cell proliferation.
Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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