Thermo Fisher Scientific RRP4 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
WKVETNSRLDS VLLLSSMNLP GGELRRRSAE DELAMRGFLQ EGDLISAEVQ AVFSDGAVSL HTRSLKYGKL GQGVLVQVSP SLVKRQKTH

Highest antigen sequence identity to orthologs:

• Mouse: 100%
• Rat: 98%

Target Information

RRP4 is a non-catalytic component of the RNA exosome complex with 3'→5' exoribonuclease activity, participating in various RNA processing and degradation pathways.

• In the nucleus, the RNA exosome complex is involved in maturation of stable RNAs (rRNA, snRNA, snoRNA), elimination of RNA processing by-products, and degradation of defective mRNAs.
• In the cytoplasm, it contributes to general mRNA turnover, degradation of AU-rich element (ARE)-containing mRNAs, and RNA surveillance pathways.
• The complex also plays a role in histone mRNA degradation and may participate in Ig class switch recombination (CSR) and somatic hypermutation (SHM).
• The Exo-9 core complex acts as a scaffold for catalytic subunits and accessory proteins, with EXOSC2 stabilizing the RNase PH-domain subunits through interaction with EXOSC4 and EXOSC7.
  [Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.