Thermo Fisher Scientific FZD7 Polyclonal Antibody
Rabbit polyclonal antibody targeting human FZD7, validated for IHC (paraffin). Reacts with Bat, Bovine, and Human species. Supplied as unconjugated liquid form with 1 mg/mL concentration. Ideal for Wnt signaling and FZD7 receptor research.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminal extracellular domain of human FZD7 / Frizzled 7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550940 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant, Bovine, Bat, Opossum (100%).
Target Information
Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.
The FZD7 protein contains:
- N-terminal signal sequence
- 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members
- 7 putative transmembrane domains
- Intracellular C-terminal tail with a PDZ domain-binding motif
FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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