Thermo Fisher Scientific Reelin Polyclonal Antibody
Reelin 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 랫드 반응성. 고순도 친화 크로마토그래피 정제 제품으로 안정적 액상 형태 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 50–190 of human RELN (NP_005036.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.21 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914167 |
Product Specific Information
- Positive test controls include: U-87MG, C6, LO2, HepG2
- Immunogen sequence:
KISTKNPDFL KDDFEGQLES DRFLLMSGGK PSRKCGILSS GNNLFFNEDG LRMLMTRDLD LSHARFVQFF MRLGCGKGVP DPRSQPVLLQ YSLNGGLSWS LLQEFLFSNS SNVGRYIALE IPLKARSGST RLRWWQPSEN GHFYSPWVID QILIGGNISG N
Target Information
Reelin is an extracellular matrix serine protease that plays a role in the layering of neurons in the cerebral cortex and cerebellum. It regulates microtubule function in neurons and neuronal migration, and affects migration of sympathetic preganglionic neurons in the spinal cord, acting as a barrier to neuronal migration. Its enzymatic activity modulates cell adhesion. Binding to extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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