Thermo Fisher Scientific DENND5A Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DENND5A. Recombinant protein control fragment (Product #RP-100832). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DENND5A,uniProtId:Q6IQ26-1,ncbiNodeId:9606,antigenRange:815-867,antigenLength:1287,antigenImageFileName:PA5-63049_DENND5A_Q6IQ26-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63049_DENND5A_Q6IQ26-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640522

Product Specific Information

Immunogen sequence: SALWSHLLHY QDNRQRKLTS GSLSTSGILL DSERRKSDAS SLMPPLRISL IQD

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.

Target Information

DENND5A (DENN domain-containing protein 5A) is a guanine nucleotide exchange factor (GEF) which activates RAB6A and RAB39A/RAB39B. It promotes the exchange of GDP to GTP by converting inactive GDP-bound Rab proteins to their active GTP form. DENND5A is also involved in the negative regulation of neurtie outgrowth. Mutations affecting this gene can result in epileptic encephalopathy, early infantile, 49 (EIEE49).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.