Thermo Fisher Scientific CD56 Monoclonal Antibody (MEM-188), PE-Cyanine5.5
인간 CD56 단백질을 인식하는 Mouse IgG2a 단클론 항체로, PE-Cyanine5.5 형광 접합체입니다. Flow Cytometry 분석에 적합하며, 488 nm 레이저로 다중 표지 검출 가능. 신경 및 면역세포 표지에 유용하며, 고감도 신경내분비 마커로 활용됩니다.
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Applications
- Flow Cytometry (Flow): Assay-dependent
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-188 |
| Immunogen | Human CD56 |
| Conjugate | PE-Cyanine5.5 |
| Excitation / Emission Max | 564 / 692 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with sucrose, BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10372061 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 647
- Biotin
- FITC
- PE
- PE-Texas Red
- TRI-COLOR
- Request custom conjugation available
Product Specific Information
The R-phycoerythrin (PE)-Cy5.5 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source — the 488 nm line of the argon-ion laser.
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that functions as an adhesive molecule. It is widely expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is present on T cells and NK cells and plays roles in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions with extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. It serves as a highly sensitive neuroendocrine marker for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
Analyte Specific Reagent
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