Thermo Fisher Scientific CD56 Monoclonal Antibody (MEM-188), PE-Cyanine5.5

Applications

• Flow Cytometry (Flow): Assay-dependent
  View 1 publication

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 647
• Biotin
• FITC
• PE
• PE-Texas Red
• TRI-COLOR
• Request custom conjugation available

Product Specific Information

The R-phycoerythrin (PE)-Cy5.5 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source — the 488 nm line of the argon-ion laser.

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that functions as an adhesive molecule. It is widely expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is present on T cells and NK cells and plays roles in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions with extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. It serves as a highly sensitive neuroendocrine marker for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

Analyte Specific Reagent

제품 이미지