Thermo Fisher Scientific Arginase 1 (ARG1) Monoclonal Antibody (OTI1H4)

Applications

• Western Blot (WB): 1:500 dilution tested

Product Specifications

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 limits substrate availability for NO synthase, thereby down-regulating nitric oxide production. In both humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells. In humans, it is expressed in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a). It is also found in myeloid cells infiltrating tumors and is prevalent in hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.