Thermo Fisher Scientific Phospho-Jak3 (Tyr980, Tyr981) Recombinant Rabbit Monoclonal Antibody (JAK3Y980981-E10), APC
APC 형광으로 표지된 재조합 Rabbit Monoclonal 항체로, 인간 JAK3의 Tyr980/981 인산화 형태를 검출합니다. Flow Cytometry에 최적화되어 있으며, HEK293 발현 시스템에서 생산되었습니다. 고순도 Protein A/G 정제 및 PBS/BSA 버퍼로 안정적 보관이 가능합니다.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JAK3Y980981-E10 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr980/981 of human Jak3 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897385 |
Additional Formats
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to various cytokines or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at two adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT proteins, which dimerize and translocate to the nucleus, modifying transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for IFN gamma-receptor complex initiation, and JAK1 functions as an amplifier. Active JAK1 may be required for complex responses. Some studies suggest that JAK2’s role might be performed by Tyk2 and JAK3 if positioned correctly within the IFN gamma-receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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