Thermo Fisher Scientific Interferon gamma (IFNG) Monoclonal Antibody (IFNG/466)
인간 IFN-γ 단백질을 인식하는 마우스 단일클론 항체로, IHC, ICC/IF, Flow Cytometry 등에 사용 가능. 비접합 형태로 제공되며, 고순도 Protein A/G 정제. 4°C 보관, 연구용 전용.
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Interferon gamma (IFNG) Monoclonal Antibody (IFNG/466)
Thermo Fisher Scientific Interferon gamma (IFNG) Monoclonal Antibody (IFNG/466)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IFNG/466 |
| Immunogen | Purified recombinant human full-length IFNG protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Interferon gamma (IFN-γ, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin, and other cytokines.
IFN-γ is a dimeric glycoprotein composed of two 146 amino acid subunits, functioning as a homodimer of approximately 45 kDa. On SDS-PAGE, it appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
The biological activity of IFN-γ is highly species-specific; human IFN-γ does not cross-react with mouse. Its functions include:
- Antiviral and tumor antiproliferative activity
- Induction of class I and II MHC expression
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
IFN-γ acts synergistically with other cytokines and signals through IFN-γ receptor I and II, activating the JAK-STAT pathway. It shares about 40% sequence homology with mouse IFN-γ and is upregulated by IL2, FGF basic, and EGF, while downregulated by vitamin D3 or DMN. Mutations in the IFN-γ gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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