Thermo Fisher Scientific TNP2 Polyclonal Antibody
Thermo Fisher Scientific의 TNP2 Polyclonal Antibody는 인간 TNP2 단백질을 특이적으로 인식하는 토끼 IgG 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공됩니다.
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Thermo Fisher Scientific TNP2 Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:3,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNP2 (Accession Q05952), corresponding to amino acid residues Q39–H89 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815994 |
Product Specific Information
This antibody detects endogenous levels of total TNP2.
Target Information
During mammalian spermiogenesis, histones are transiently replaced by several low molecular weight proteins called transition proteins (TNPs). These proteins facilitate chromatin transformation from the nucleosome structure to the nucleoprotamine structure during spermatid differentiation.
Transition protein-2 (TNP2, TP2) maps to human chromosome 16p13.13 and encodes a highly basic nuclear protein. TNP2 is a spermatid-specific product of the haploid genome that replaces histone and is later replaced by protamines in mature sperm.
Although TNP2 is not essential for sperm nucleus shaping or fertility, it is crucial for proper protamine 2 processing and chromatin condensation. In the absence of TNP1, TNP2 may partially compensate, but this leads to abnormal chromatin condensation and reduced fertility.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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