Thermo Fisher Scientific BPI Monoclonal Antibody (04)
Human BPI 단백질을 인식하는 Mouse monoclonal antibody로 ELISA에 적합합니다. 보존제가 없는 액상 형태이며 Protein A로 정제되었습니다. 단기 4°C, 장기 -20°C 보관을 권장합니다. 항균 단백질 BPI 연구용으로 적합합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 04 |
| Immunogen | Recombinant Human BPI protein (Met1–Lys487) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785876 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human BPI.
Target Information
The antimicrobial protein BPI (Bactericidal/Permeability-Increasing protein) is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and is also detected on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI binds with high affinity to the lipid A region of lipopolysaccharides (LPS) in gram-negative bacterial membranes, leading to multiple anti-infective activities such as:
- Cytotoxicity via damage to bacterial membranes
- Neutralization of LPS
- Opsonization to enhance phagocytosis by neutrophils
BPI may play a critical role in LPS-triggered airway diseases and inflammation related to hematopoietic cell transplantation.
A recombinant fragment, rBPI21 (21 kDa), has shown protective effects against invasive pneumococcal disease by binding to pneumolysin, a gram-positive bacterial toxin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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