ELK Biotechnology NHRF1 rabbit pAb
NHRF1 단백질을 인식하는 토끼 폴리클로날 항체로 WB 및 ELISA에 사용 가능. 인간, 생쥐, 랫트에 반응하며 세포질 및 세포막 부위에 위치. 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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ELK Biotechnology NHRF1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | NHRF1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 39 kD |
| Gene ID (Human) | 9368 |
| Human Swiss-Prot No. | O14745 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, apical cell membrane, endomembrane system; peripheral membrane protein. Found in filopodia, ruffling membrane, microvilli, and lipid rafts. Translocates from cytoplasm to apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR and actin in microvilli-rich regions. |
Background
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. It also interacts with linker proteins between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene cause hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity is implicated in breast cancer. [RefSeq, Sep 2009]
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