ELK Biotechnology GDF1 rabbit pAb
GDF1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, -20°C에서 1년간 보관 가능합니다. TGF-beta 신호전달 관련 단백질 연구에 유용합니다.
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제품명
GDF1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB, ELISA |
| Recommended Dilutions | WB 1:500–1:2000, ELISA 1:5000–1:20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 321–370) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kD |
| Gene ID (Human) | 2657 |
| Human Swiss-Prot No. | P27539 |
| Cellular Localization | Secreted |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. (RefSeq, Jul 2016)
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