ELK Biotechnology ACVR1 rabbit pAb
ACVR1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 생쥐, 랫트 시료에 반응하며, 세포막 단백질 검출에 적합. 안정적인 -20°C 보관으로 1년간 유지 가능.
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ACVR1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ACVR1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| Gene ID (Human) | 90 |
| Human Swiss-Prot No | Q04771 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Storage | -20°C, 1 year |
Background
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-β) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases, including at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are transmembrane proteins composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine kinase specificity. Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression. After ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor, which participates in specific signaling pathways.
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