ELK Biotechnology TRXR1 rabbit pAb
TRXR1 rabbit pAb는 인간, 쥐, 생쥐에서 반응하는 폴리클로날 항체로 WB와 ELISA 실험에 적합합니다. 인간 단백질 유래 펩타이드로 면역생성되었으며, 산화 스트레스 보호 및 셀레늄 대사 연구에 활용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology TRXR1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TRXR1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein (AA range: 268–318) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 71 kD |
| GeneID (Human) | 7296 |
| Human Swiss-Prot No | Q16881 |
| Cellular Localization | [Isoform 1]: Cytoplasm; [Isoform 4]: Cytoplasm, Nucleus; [Isoform 5]: Cytoplasm |
| Species Reactivity | Human; Rat; Mouse |
Background
Thioredoxin reductase 1 (TXNRD1) is a member of the pyridine nucleotide oxidoreductase family. This enzyme reduces thioredoxins and other substrates, playing an essential role in selenium metabolism and protection against oxidative stress. The active enzyme functions as a homodimer using FAD as a cofactor, with each subunit containing a selenocysteine (Sec) residue crucial for catalytic activity. The Sec residue is encoded by a UGA codon, typically signaling translation termination, but recognized as Sec through a specific stem-loop structure (SECIS) in the 3′ UTR. Alternative splicing generates multiple transcript variants encoding identical or distinct isoforms. [RefSeq, Jul 2008]
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