ELK Biotechnology PABP1 rabbit pAb
PABP1 rabbit polyclonal antibody for WB and ELISA applications. Recognizes human, rat, and mouse proteins. Targets poly(A) binding protein involved in mRNA translation and decay. Stored at -20°C for up to 1 year.
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ELK Biotechnology PABP1 rabbit pAb
제품 개요
PABP1 rabbit polyclonal antibody는 인간, 쥐, 생쥐 단백질에 반응하며, WB 및 ELISA 실험에 적합합니다. Poly(A) binding protein을 인식하여 mRNA 번역 및 안정성 연구에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | PABP1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein (AA range: 212–262) |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 69 kD |
| GeneID (Human) | 26986 |
| Human Swiss-Prot No | P11940 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm, Stress granule, Nucleus, Cell projection (lamellipodium).
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Shuttles between the cytoplasm and nucleus.
During stress or absence of DDX3X, localizes to nucleus.
At leading edge of migrating fibroblasts, colocalizes with DDX3X.
Relocalizes to cytoplasmic stress granules upon cellular stress, colocalizing with ENDOV.
In HRSV infection, localizes in cytoplasmic inclusion bodies (IBAGs).
Background
This gene encodes a poly(A) binding protein that shuttles between nucleus and cytoplasm, binding to the 3′ poly(A) tail of eukaryotic mRNAs via RNA-recognition motifs. It promotes ribosome recruitment and translation initiation, and is required for poly(A) shortening — the first step in mRNA decay. The gene belongs to a small family with three protein-coding genes and several pseudogenes. (RefSeq, Aug 2010)
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