ELK Biotechnology MRGX2 rabbit pAb
MRGX2 단백질을 인식하는 토끼 폴리클로날 항체로 WB와 ELISA에 적합합니다. 인간 및 마우스 시료에 반응하며, 세포막 단백질 분석에 유용합니다. 고순도 IgG 형태로 −20°C에서 1년간 보관 가능합니다.
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제품명
MRGX2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 250–330) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kD |
| Gene ID (Human) | 117194 |
| Human Swiss-Prot No | Q96LB1 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse |
| Storage | −20°C / 1 year |
Background
Function: Orphan receptor, probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high-potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation, locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Similarity: Belongs to the G-protein coupled receptor 1 family, Mas subfamily.
Tissue Specificity: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
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