ELK Biotechnology HCAR2 rabbit pAb
HCAR2 rabbit polyclonal antibody로 인간, 랫, 마우스에 반응하며 WB 및 ELISA에 적합합니다. 고순도 IgG 형식으로 세포막 단백질 검출에 유용하며, 안정적 저장(-20°C/1년) 및 높은 특이성을 제공합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology HCAR2 rabbit pAb
제품명
HCAR2 rabbit pAb
적용 분야
- Western Blot (WB)
- ELISA
권장 희석 배율
- WB: 1:500–1:2000
- ELISA: 1:5000–1:20000
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from human protein (AA range: 260–340) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 39 kD |
| Gene ID (Human) | 338442 |
| Human Swiss-Prot No | Q8TDS4 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
Expression in neutrophils occurs in the late terminal differentiation phase. Acts as a high-affinity receptor for both nicotinic acid (niacin) and (D)-beta-hydroxybutyrate, mediating increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This effect requires nicotinic acid doses higher than dietary levels. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid reduces cAMP levels, affecting cAMP-dependent protein kinase A activity and leading to neutrophil apoptosis.
Miscellaneous:
Potency order for nicotinic acid binding displacement:
5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity:
Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.