ELK Biotechnology LGR5 rabbit pAb
LGR5 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 및 골지체에 위치한 단백질 검출에 사용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology LGR5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | LGR5 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 99 kD |
| GeneID (Human) | 8549 |
| Human Swiss-Prot No | O75473 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Multi-pass membrane protein.
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Rapidly and constitutively internalized to the trans-Golgi network at steady state.
Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
Background
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily.
The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway.
This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development.
Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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