ELK Biotechnology LDB3 rabbit pAb

ELK Biotechnology LDB3 rabbit pAb

제품 설명

LDB3 단백질을 인식하는 토끼 다클론 항체입니다. 인간 및 생쥐 시료에서 WB 및 ELISA 분석에 활용할 수 있으며, 세포질 및 근섬유 Z선 부위 단백질 검출에 적합합니다.

제품 사양

Background

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80–120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins.
The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50–60 amino acids containing two zinc-binding modules.
This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms contain LIM domains.