Thermo Fisher Scientific Phospho-CaMKII alpha (Thr286) Recombinant Rabbit Monoclonal Antibody (10G8J4)
Recombinant rabbit monoclonal antibody targeting phospho-CaMKII alpha (Thr286). Validated for Western blot and ELISA. High specificity to mouse and rat samples. Supplied in liquid form with 0.59 mg/mL concentration. Suitable for research use in neurona...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10G8J4 |
| Immunogen | A synthetic phosphorylated peptide around T286 of human CaMK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.59 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
- Immunogen Sequence: QETVD
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates various cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostasis.
Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling a switch from calmodulin-dependent to calmodulin-independent activity.
CaMKII plays essential roles in dendritic spine and synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle. In neurons, it contributes to actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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