Thermo Fisher Scientific MTH1 Polyclonal Antibody
Thermo Fisher Scientific의 MTH1 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간 NUDT1 유래 합성 펩타이드로 제작된 비결합 항체로, 산화 스트레스 관련 DNA 손상 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human NUDT1 (Accession P36639), residues G62–G83 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852171 |
Product Specific Information
This antibody detects endogenous levels of total NUDT1.
Target Information
Oxygen radicals damage chromosomal DNA, causing cell death and mutations. Among various DNA damages, oxidized guanine (8-oxoguanine) is significant as it can pair aberrantly with cytosine or adenine, leading to G:C to T:A transversion mutations. Mammalian cells produce substantial 8-oxoG in chromosomal DNA, most of which is excised and excreted in urine. During oxidative stress, 8-oxo-deoxyguanosine (8-oxo-dGTP) forms in the nucleotide pool and may be misincorporated into DNA unless repaired. MTH converts 8-oxo-dGTP to the monophosphate form, preventing misincorporation into DNA. MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA and cause missense or nonsense protein production.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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