Thermo Fisher Scientific GAB1 Monoclonal Antibody (1AT1979)
GAB1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 적합합니다. 세포 성장, 신호전달 및 아폽토시스 연구에 활용 가능합니다. 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관이 권장됩니다.
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- MA537646
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1AT1979 |
| Immunogen | GST fusion protein encoding full length human GAB1 (UniProt ID: Q13480-1, antigen range: 1–694) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation, and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinases (RTKs), including insulin receptor (IR), platelet-derived growth factor receptor beta (PDGFRβ), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met), and epidermal growth factor receptor (EGFR), as well as in response to cell-cell adhesion.
Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphatidylinositol 3-kinase (PI3K), Grb2, PLCγ1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2 and for activation of the ERK/MAPK pathway in response to EGF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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