Thermo Fisher Scientific RIP3 Polyclonal Antibody
RIP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능하며, 인간 반응성 확인. Protein A로 정제된 액상 형태로 제공되며, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific RIP3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.25 µg/mL | - |
| Immunohistochemistry (IHC) | Assay-dependent | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human RIP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688382 |
Product Specific Information
This target displays homology in the following species:
- Cow: 79%
- Dog: 93%
- Horse: 86%
- Human: 100%
- Mouse: 86%
- Pig: 86%
- Rat: 91%
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a unique C-terminal domain distinct from other RIP family members. RIPK3 is mainly localized in the cytoplasm and mitochondria and can undergo nucleocytoplasmic shuttling via nuclear localization and export signals. It is part of the TNF receptor-I signaling complex, capable of inducing apoptosis and weakly activating NF-kappaB. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, which is essential for its protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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