Thermo Fisher Scientific HAS3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

• Immunogen sequence:
  RQEDAYMLDI FHEVLGGTEQ AGFFVWRSNF HEAGEGETEA SLQEGMDRVR DVVRASTFSC
• Highest antigen sequence identity to orthologs:
  • Mouse: 93%
  • Rat: 95%

Target Information

HAS1, HAS2, and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins.
HA is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds.
The three HAS genes show distinct expression patterns during development and play different roles in HA matrix formation.

• HAS1 and HAS2 synthesize high molecular-weight HA.
• HAS3 produces lower molecular-weight HA and is the most active isoform in adults.
  HAS3 expression is crucial for regulating hyaluronan synthesis in the epidermis. IFN-γ upregulates HAS3 mRNA, while TGF-β downregulates it.
  The human HAS3 gene maps to chromosome 16q22.1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.