Thermo Fisher Scientific HAS3 Polyclonal Antibody
Human HAS3 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:200–1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. HAS3 관련 하이알루론산 합성 연구에 적합. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HAS3. Recombinant protein control fragment (Product #RP-95699) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642313 |
Product Specific Information
- Immunogen sequence:
RQEDAYMLDI FHEVLGGTEQ AGFFVWRSNF HEAGEGETEA SLQEGMDRVR DVVRASTFSC - Highest antigen sequence identity to orthologs:
- Mouse: 93%
- Rat: 95%
Target Information
HAS1, HAS2, and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins.
HA is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds.
The three HAS genes show distinct expression patterns during development and play different roles in HA matrix formation.
- HAS1 and HAS2 synthesize high molecular-weight HA.
- HAS3 produces lower molecular-weight HA and is the most active isoform in adults.
HAS3 expression is crucial for regulating hyaluronan synthesis in the epidermis. IFN-γ upregulates HAS3 mRNA, while TGF-β downregulates it.
The human HAS3 gene maps to chromosome 16q22.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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