Thermo Fisher Scientific FOXK1 Polyclonal Antibody
FOXK1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간 FOXK1의 683–733번 잔기 영역을 면역원으로 사용하며, 4°C에서 보관 가능합니다. 세포 대사 및 근육 분화 연구에 활용됩니다.
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- A301728Ax (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific FOXK1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 683 and 733 of human forkhead box K1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
FOXK1 is a transcriptional regulator involved in glucose metabolism, aerobic glycolysis, muscle cell differentiation, and autophagy. It recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3'), acting as both activator and repressor depending on context.
Together with FOXK2, FOXK1 regulates metabolic reprogramming toward aerobic glycolysis by promoting glycolytic enzyme expression (HK2, PFK, PKLR, LDH) and suppressing pyruvate oxidation via PDK1 and PDK4.
It participates in gluconeogenesis during fasting and in mTORC1-mediated metabolic reprogramming, influencing genes like HIF1A. FOXK1 also acts as a negative regulator of autophagy in skeletal muscle, repressing autophagy gene expression during starvation.
Additionally, FOXK1 regulates myogenic progenitor cell populations, represses FOXO4-mediated differentiation, and contributes to muscle repair processes. It enhances Wnt/β-catenin signaling by nuclear translocation of DVL and promotes antiviral gene expression by binding ISRE elements.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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