Thermo Fisher Scientific CISD2 Polyclonal Antibody
CISD2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 IHC에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 2–8°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 5 publications |
| Immunohistochemistry (IHC) | 2.5 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the center of human CISD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551897 |
Product Specific Information
- A suggested positive control is rat brain tissue lysate.
- PA5-34545 can be used with blocking peptide PEP-1588.
Target Information
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2.
CISD2 is a zinc finger protein localized to the endoplasmic reticulum and mitochondria, binding an iron/sulfur cluster.
It interacts with Bcl-2 and can be displaced by the BH3-only protein BIK, contributing to the regulation of BIK-initiated autophagy.
CISD2 deficiency in mice causes mitochondrial breakdown, autophagic cell death, and premature aging phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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