Thermo Fisher Scientific SH2D1A Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP

Target Information

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. It contains an SH2 domain and a short tail, and associates with the signaling lymphocyte-activation molecule (SLAM), acting as an inhibitor by blocking SHP-2 recruitment to its docking site.
It also binds to related surface molecules on activated T, B, and NK cells, modifying signal transduction pathways.
Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 (Duncan disease), a rare immunodeficiency associated with Epstein–Barr virus susceptibility, severe mononucleosis, and malignant lymphoma. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.