Thermo Fisher Scientific CSNK2A2 Monoclonal Antibody (1E8)
CSNK2A2 단백질을 인식하는 Mouse IgG2a 단일클론 항체. Western blot, ICC/IF, ELISA에 적합하며, 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능하며, 보존 용이한 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E8 |
| Immunogen | CSNK2A2 (NP_001887.1, 1 a.a. – approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID
Target Information
Casein kinase II (CK2) is a serine/threonine kinase present in all eukaryotic cells, indicating its fundamental cellular role. The holoenzyme is a tetramer composed of two alpha or alpha-prime subunits (or one of each) and two beta subunits. The alpha subunit acts as the catalytic unit, while the beta subunit’s function remains unclear.
CK2 phosphorylates key intracellular signaling proteins involved in tumor suppression (p53, PTEN) and tumorigenesis (myc, jun, NF-kappaB). It also influences Wnt signaling through beta-catenin phosphorylation and the PI3K pathway via Akt phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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