Thermo Fisher Scientific UBASH3A Polyclonal Antibody

Thermo Fisher Scientific UBASH3A Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:3,000
  View 1 publication

Product Specifications

Product Specific Information

• Recommended positive controls: THP-1
• Predicted reactivity: Human (99%), Dog (81%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized to both nucleus and cytoplasm. It contains one SH3 domain and one UBA domain, and is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes.
TULA forms homodimers or homo-oligomers that interfere with degradation of receptor-type tyrosine kinases, promoting accumulation of activated receptors on the cell surface. It is part of an EGFR- and Cbl-containing complex interacting with ubiquitinated proteins.
The gene encoding TULA maps to human chromosome 21 and may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced through alternative splicing.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.