Thermo Fisher Scientific ISG15 Recombinant Rabbit Monoclonal Antibody (16D8)

Applications and Tested Dilution

Product Specifications

Target Information

Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection, either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and promotes NK-cell proliferation and non-MHC-restricted cytotoxicity.
ISG15 synthesis is stimulated by IFN-α, IFN-β, or IFN-ω, but not IFN-γ. Expression is also induced by overexpression of interferon regulatory factors and by influenza B virus.
It is secreted by monocyte, T-lymphocyte, B-lymphocyte, fibroblast, and epithelial cell lines. ISG15 functions as part of the cytokine cascade, amplifying immunomodulatory effects of type I interferons, and also acts intracellularly as a ubiquitin homolog.
Mutations in the ISG15 gene can result in Immunodeficiency 38 with basal ganglia calcification (IMD38).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.