Thermo Fisher Scientific DNA-PKcs Polyclonal Antibody
Goat 폴리클로날 항체로 DNA-PKcs를 인식하며, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간 단백질 잔기 4078–4128 영역을 면역원으로 사용하였으며, 액상 형태로 1 mg/mL 농도입니다. 4°C 보관, Wet ice 배송, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific DNA-PKcs Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 4078 to 4128 of human Protein Kinase, DNA-Activated, Catalytic Polypeptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase, closely related to PI3 kinases, and often inhibited by small molecules targeting PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting formation of a transcriptional pre-initiation complex.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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