Thermo Fisher Scientific GPCR HM74 Polyclonal Antibody
Thermo Fisher Scientific GPCR HM74 Polyclonal Antibody는 인간 GPCR HM74를 인식하는 토끼 폴리클로날 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 고순도 Protein A 정제, 안정적인 액상 형태로 제공되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GPCR HM74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Acts as a high affinity receptor for both nicotinic acid (niacin) and (D)-beta-hydroxybutyrate. Mediates increased adiponectin secretion and decreased lipolysis via G(i)-protein-mediated inhibition of adenylyl cyclase. This effect requires nicotinic acid doses higher than those from a normal diet. Also mediates nicotinic acid-induced apoptosis in mature neutrophils through reduced cAMP levels, affecting cAMP-dependent protein kinase A activity and phosphorylation of target proteins. The rank order of potency for displacement of nicotinic acid binding is:
5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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