Thermo Fisher Scientific Bovine FGF-basic (FGF-2/bFGF), Animal-Free Recombinant Protein, PeproTech

Applications

• Functional Assay (Functional)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

Recombinant Bovine FGF-basic is a 17.1 kDa protein consisting of 154 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of transmembrane receptor pathways.
In humans, the gene is located on the q arm of chromosome 4. FGF2 is implicated in various biological processes such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties.
CUG-initiated isoforms are nuclear and responsible for intracrine effects, while the AUG-initiated form is cytosolic and mediates paracrine and autocrine functions.
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.