Thermo Fisher Scientific MCF2 Monoclonal Antibody (OTI2C12), TrueMAB
MCF2 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, 비결합형 액상 형태로 제공. 연구용으로 GTPase 조절 관련 단백질 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 872–1001 of human MCF2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some members of the Rho family GTPase from the GDP-bound to the GTP-bound form.
Isoform 1 exhibits no activity toward RHOA, RAC1, or CDC42.
Isoform 2 exhibits decreased GEF activity toward CDC42.
Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42.
Isoform 4 exhibits significant activity toward RHOA and CDC42.
The truncated DBL oncogene is active toward RHOA, RAC1, and CDC42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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