Thermo Fisher Scientific GEP100/IQSEC1 Polyclonal Antibody
GEP100/IQSEC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 고순도 액상 형태로 연구용에 적합.
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Thermo Fisher Scientific GEP100/IQSEC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GEP100, amino acids 451–550 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ADP ribosylation factors (Arfs) are small GTP-binding proteins involved in vesicular transport, where they nucleate the assembly of coat protein complexes at carrier vesicle formation sites.
IQSEC1 (also known as GEP100/BRAG2) is a guanine nucleotide exchange protein for ARF6, belonging to the BRAG family. It contains one IQ domain, one PH domain, and one SEC7 domain. As an activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin, and its knockdown has been shown to block tumor metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to cancer metastasis and malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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