Thermo Fisher Scientific ABCD4 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
TLVSKNAFVC IYLISCFTQL IDLSTTLSDV AGYTHRIGQL RETLLDMSLK SQDCEILGES EWGLDTPPGW PAAEPADTAF LLERVSISAP SSDKPLIKDL SLKISEGQSL LITGNTGTGK

Target Information

The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1–4, that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter.
A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder affecting lipid storage.
ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD.
The peroxisomal membrane comprises two major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors.
ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.