Thermo Fisher Scientific CHST15 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: Raji
• Predicted reactivity: Mouse (94%), Rat (94%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

GALNAC4S-6ST is a sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A, forming chondroitin sulfate E containing GlcA-GalNAc(4,6-SO₄) repeating units.
It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO₄)-GlcA(2SO₄)-GalNAc(6SO₄), yielding a highly sulfated structure similar to that found in thrombomodulin chondroitin sulfate.
GALNAC4S-6ST may also act as a B-cell receptor involved in early activation and regulation of B-cell-specific RAG expression, though such results remain unclear in vivo.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.