Thermo Fisher Scientific CEA (CEACAM5) Monoclonal Antibody (OTI3E10), TrueMAB
Human CEACAM5(CD66e) 인식 단일클론 항체로 Western blot 및 IHC(P) 검증됨. TrueMAB 포맷, Mouse IgG1 형식이며 비결합 상태로 제공. 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 종양 표지자 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 35–680 of human CEACAM5 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CEA (Carcino Embryonic Antigen, CD66e) is synthesized during fetal development in the gut and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family, consisting of a single N domain and six immunoglobulin constant-like domains (A1, A2, A3, B1, B2, B3).
Antibodies to CEA help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell adhesion molecule expressed on leukocytes, epithelia, and endothelia, mediating homophilic and heterophilic binding. It plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants encoding different isoforms have been reported, though not all are fully defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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