Thermo Fisher Scientific CD22/BLCAM Polyclonal Antibody
CD22/BLCAM 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. IHC, ICC/IF, ELISA 등 다양한 면역분석에 적합. 인간, 마우스, 랫트 반응성. Protein A로 정제된 액상 항체로 -20°C 보관.
- 카탈로그번호
- BS-1481R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD22/BLCAM Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CD22, amino acids 701–847 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with a molecular weight of 130–140 kDa. It is expressed in both the cytoplasm and cell membrane of B-lymphocytes and appears early in B-cell differentiation, similar to CD19.
CD22 expression is restricted to mature B cells and is absent in plasma cells, making it useful for phenotyping mature leukemias. It is strongly expressed in hairy cell leukemia, diffuse large B-cell lymphoma, and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
CD22 preferentially binds to α2,6-linked sialic acid, and its recognition site can be masked by cis interactions. Upon ligand-induced tyrosine phosphorylation, CD22 participates in the regulation of B-cell receptor signaling, acting as both a positive and inhibitory regulator through interactions with Src family kinases and phosphatases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.