Thermo Fisher Scientific FMO5 Polyclonal Antibody
인간 FMO5 단백질을 인식하는 Rabbit Polyclonal 항체입니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 포함) 용액 형태로 제공되며, 연구용으로만 사용됩니다.
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- PA552932
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FMO5. Recombinant protein control fragment (Product # RP-90221) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641688 |
Product Specific Information
Immunogen sequence:
PLGAIMPISE LQGRWATQVF KGLKTLPSQS EMMAEISKAQ EEIDKRYVES QRHTIQGDYI DTMEELADLV GVRPNLLSLA FTDPKLALHL LLGPCTPIHY RVQGPGKWDG ARKAILTTDD
Sequence identity with orthologs:
- Mouse: 85%
- Rat: 86%
Target Information
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans, resulting in a subpopulation with reduced TMA N-oxidation capacity (fish odor syndrome, Trimethylaminuria).
Three forms of the enzyme — FMO1 (fetal liver), FMO2 (adult liver), and FMO3 — are encoded by genes clustered in the 1q23–q25 region.
Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyze the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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