Thermo Fisher Scientific MAPK13 Monoclonal Antibody (2B2)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDRRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL

Target Information

MAPK13 (p38 delta) is a serine/threonine kinase that transduces various extracellular signals, including cytokine and environmental stress responses. It regulates keratinocyte differentiation and is activated by environmental stresses and proinflammatory cytokines. Activation occurs via phosphorylation by MAP kinase kinases or autophosphorylation triggered by MAP3K7IP1/TAB1 interaction.

Substrates of MAPK13 include:

• Transcription regulators (ATF2, MEF2C, MAX)
• Cell cycle regulator (CDC25B)
• Tumor suppressor (p53)

These interactions suggest roles in stress-related transcription, cell cycle regulation, and genotoxic stress response.
Four alternatively spliced transcript variants of SAPK4 encoding distinct isoforms have been reported.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.