Thermo Fisher Scientific FSHR Polyclonal Antibody

Thermo Fisher Scientific FSHR Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 10–20 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey, Marmoset (100%)
Gibbon, Dog, Bat, Elephant, Rabbit, Horse, Pig, Guinea pig (94%)

Target Information

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.