Thermo Fisher Scientific FSHR Polyclonal Antibody
FSHR 단백질을 인식하는 Rabbit 폴리클로날 항체로, 인간 및 비인간 영장류 시료에 반응합니다. IHC(P)에서 10–20 µg/mL로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS에 0.1% sodium azide 포함, 4°C 또는 -20°C 보관.
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Thermo Fisher Scientific FSHR Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 10–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human FSHR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550927 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey, Marmoset (100%)
Gibbon, Dog, Bat, Elephant, Rabbit, Horse, Pig, Guinea pig (94%)
Target Information
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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